Osteorradionecrose em mandíbula
Palavras-chave:
Mandíbula , Osteorradionecrose , RadioterapiaResumo
A mandíbula está entre os ossos mais frequentemente afetados pela radiação. A mais severa sequela pós-radiação da mandíbula é a osteorradionecrose. Após tratamento de radioterapia em casos de câncer da cabeça e do pescoço, ela varia de pequenas exposições ósseas assintomáticas (que podem permanecer estáveis de meses a anos ou cicatrizar com tratamento conservador) até necrose severa, que requer intervenção cirúrgica e reconstrução. Está claro que as causas e a patogenia da osteorradionecrose são muito mais complexas do que se acreditava. Para o correto tratamento odontológico de pacientes irradiados, deve-se prevenir esta patologia.
Downloads
Referências
Ewing J. Radiation osteitis. Acta Radiol. 1926; 6:399-412.
Teng MS, Futran ND. Osteoradionecrosis of the rnandible. Curr Opin OtoÊaryngol Head Neck Surg. 2005; 13(4):217-21.
Store G, Boysen M. Mandibular osteoradionecrosis clinical behavior and diagnostic aspects. Clin Otolaryngol. 2000; 25(5):378-84.
Mendenhall WM. Mandibular osteoradionecrosis. J Clin Oncol. 2004; 22(24):4867-8.
Studer G, Glanzmann C. Gratz KW. Osteoradionecrosis of the mandible in patients treated with different fractionations. Strahlenther Onkol. 2004; 180(4):233-40.
Lozza L, Cerrotta A, Gardani G. De Marie M. Di Russo A, Kenda R, et al, Analysis of risk factors for mandibular
bone radionecrosis after exclusive low dose-rate brachytherapy for oral cancer. Radiother Oncol. 1997; 44(2): 143-7.
Makkonen TA, Kiminki A. Makkonen TK. Nordman E Dental extractions in relation to radiation therapy of 224 patients. Int J Oral Maxillofac Surg. 1987; 16(1):56-64.
Marx RE. Osteoradionecrosis. A new concept in its pathophysiology. J Oral Maxillofac Surg. 1983; 41 (5):283-8.
Westermark A, Sindet-Pederson S, Jensen J. Osteoradionecrosis: pathogenesis, treatment and prevention. Tandlaegebladet, 1990; 94(16):669-73.
Murray C, Herson J, Zimmerman S. Radiation necrosis of the mandible: a 10 year study: Part II: dental factors, onset, duration and management of necrosis. Int J Radiat Oncol Biol Phys. 1980; 6(5):549-53.
Jereczek-Fossa BA, Orecchia R. Radiotherapy-induced mandibular bone complications. Cancer Treat Rev. 2002; 28(1):65-74.
Bras J, Jonge HK, van Merkesteyn JP. Ostaoradionecrosis of the mandib Ie: pathogenesis, Arn J Otolaryngol. 1990; 11 (4):244-50.
Assael LA. New foundations tn understanding osteonecrosis of the jaws. J Oral Maxiflofac Surg, 2004; 62(2):125-6.
Ruggiero SL, Mehrotra B, Rosenberg TJ, Engroff SL. Osteoradionecrosis of the jaws associated with the use of bisphosphonates: a review of 63 cases. J Oral Maxillofac Surg. 2004; 62(5):527-34.
Hermans R, Fosscon E, loannides C, van den Bogaert W, Ghekiere J, Baert AL. CT findings in osteoradionecrosis of the mandible. Skeletal Radiol 1996; 25(1):31-6.
Bachmann G. Rôssler R. Klett R, Rau WS, Bauer R. The role of magnetic resonance imaging and scintigraphy
in the diagnosis of pathologic changes of the mandible after radiation theraphy. Int J Oral Maxillofac Surg. 1996; 25(3):189-95.
Kreisner PE. Oliveira MG. Weissmann R Osteorradionecrose: revista da literatura. Rev Fac Odontol Passo Fundo. 2005; 10(2):93-6.
Notani K. Yamazaki Y, Kitada H. Sakakibara N. Fukuda H, Omori K, et al. Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy.
Head Neck. 2003; 25(3): 181-6.
Chavez JÁ, Adkinson CD. Adjunctive hyperbaric oxygen in irradiated patients requiring dental extractions: outcomes and complications. J Oral Maxillofac Surg. 2001; 59(5):518-22.
Bui OC, et al. The efficacy oh hyperbaric oxygen therapy in the treatment of radiation-induced late side effects. Int J Radiat Oncol Bio Phys. 2004; 60:871-8.
Marx RE. Johnson RP. Kline SN. Prevention of osteoradionecrosis: a randomized prospective clinical trial of hyperbaric oxygen versus penicillin. J Am Dent Assoc. 1985; 111(1):49-54.
Clayman L. Clinical controversies in oral and maxillofacial surgery: part two. Management of dental extractions in irradiated jaws: a protocol without hyperbaric oxygen therapy. J Oral Maxillofac Surg. 1997; 55:275-81.
Sulaiman F, Huryn JM, Zlotolow IM. Dental extractions in the irradiated head and neck patient: a retrospective analysis of Memorian Sloan-Kettering Cancer Center protocols, criteria, and end results J Oral Maxillofac Surg. 2003; 61 (10):1123-31.
Németh Z, Sonogyi A, Takácsi-Nagy Z, Barabás J, Németh G, Szabóg. Possibilities of preventing osteoradionecrosis during complex therapy of tumors of the oral cavity, Pathol Oncol Res, 2000; 6(1):53-8.
Wahl MJ. Osteoradionecrosis prevention myths. Int J Radiation Oncology Phys. 2006; 64(3):661-9.
Epstein JB, Wong FL, Stevenson-Moore P. Osteoradionecrosis: clinical experience and a proposal for classification J Oral Maxillofac Surg. 1987; 45(2): 104-11.
Vudiniabola S. Pirone C. Williamson J, Goss AN Hyperbaric oxygen in the prevention of osteoradionecrosis of the jaws. Aust Dent J. 1999; 44(4):243-7.
Stevenson-Moore P. Oral complications of cancer therapies essential aspects of a pretreatment oral examination. N C 1 Monogr. 1990; (9):33-6.
Jansma J, Vissink A, SpVkervet FK, Roodenburg JL, Panders AK, Vermey A, et al. Protocol for the prevention
and treatment of oral complications of head and neck radiotherapy. Cancer. 1992; 70(8):2171-80.
Thorn JJ, Hansen HS, Specht L, Boustholt L Osteoradionecrosis of the jaws: clinical characteristics and relation to the field of Irradiation. J Oral Maxillofac Surg. 2000; 58(10):1088-93.
Schiodt M, Hermund NU. Management of oral disease prior to radiation therapy. Support Care Center. 2002;
(1):40-3.
Peleg M, Lopez EA. The treatment of osteoradionecrosis of the mandible: the case for hyperbaric oxygen and bone graft reconstruction. J Oral Maxillofac Surg. 2006; 64(6):956-60.
Vissink A, Burlage FR, SpVkervet FK, Jansma J, Coppes RP. Prevention and treatment of the consequences of
head and neck radiotherapy. Crit Rev Oral Biol Med 2003; 14(3):213-25.
Annane D, Depondt J, Aubert P, Villart M, Gíhanno P, Gajdos P, Chevret S. Hyperbaric oxygen therapy for
radionecrosis of the jaw: a randomized placebocontrolled. double-blind trial. J Clin Oncol. 2004. 22(24):4893-900.
Marx RE, Johnson RP. Studies in the radiobiology of osteoradionecrosis and their clinical significance, Oral
Surg Oral Med Oral Pathol Oral Radiol Endod. 1987; 64:379-390.
Rothstein JP. Radiation therapy and oral care. Dent Today. 2005; 24:66-8.
