Polimorfismo -30G<A no gene promotor da glucoquinase: um estudo transversal de associação do mesmo com a diabetes Mellitus, hiperlipidemia, hipertensão arterial e síndrome metabólica em um hospital iraniano
Palavras-chave:
Índice de massa corporal, Glucoquinase, Síndrome metabólica, Obesidade, Polimorfismo de nucleotídeo únicoResumo
Objetivo
O polimorfismo de nucleotídeo único -30G>A, na região promotora do gene da glucoquinase, já foi associado à obesidade, resistência insulínica e diabete. O objetivo deste estudo foi avaliar a associação deste polimorfismo com a obesidade e suas comorbidades em uma população do nordeste iraniano.
Métodos
Quinhentos e quarenta e dois indivíduos com idades entre 18 e 65 anos foram divididos em três grupos: normal (BMI<25, n=220), sobrepeso (25<BMI<30, n=135) e obeso (BMI>30, n=187). Todos os indivíduos foram genotipados para o polimorfismo -30G>A através da técnica da reação em cadeia da polimerase - polimorfismo do comprimento do fragmento de restrição.
Resultados
As frequências dos genótipos e alelos dos 3 grupos não diferiram entre si (p>0,05). Quando a população de estudo foi categorizada de acordo com a presença de diabete, hiperlipidemia, hipertensão arterial e síndrome metabólica, os genótipos e alelos -30G>A dos subgrupos com e sem essas doenças não diferiram entre si (p>0,05), exceto por uma frequência maior do alelo G no grupo de hiperlipidêmicos quando comparados aos não hiperlipidêmicos (p<0,05).
Conclusão
Os achados do presente estudo não confirmam uma associação entre o polimorfismo -30G>A e excesso de peso na população iraniana.
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Copyright (c) 2023 Mohammad Reza OLADI, Javad BEHRAVAN, Mitra HASSANI, Jamal KASSAEIAN, Amirhossein SAHEBKAR, Shima TAVALLAIE, Roghayeh PAYDAR, Hamidreza SABER, Habib Allah ESMAEILI, Mohsen AZIMI-NEZHAD, Gordon FERNS, Majid GHAYOUR-MOBARHAN
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
