Potential drug-food interactions in patients hospitalized in the Cardiology Unit
Abstract
Objective
To analyze potential Drug-Food Interactions identifi ed in prescriptions of patients admitted to the CardiologyUnit of a university hospital.
Methods
This is a descriptive, cross-sectional quantitative study carried out in the Cardiology Unit of a university hospital in the city of Rio de Janeiro, Brazil. Data collection took place in archived medical records of hospitalized patients between August and September, 2016.
Results
In each prescription, there were on average 7.5 drugs mentioned (Standard Deviation of 2.1). Most were tablets (93%) a d antihypertensive drugs (40%). Two hundred and fi fty two potential Drug-Food Interactions were identifi ed. Acetylsalicylic acid and omeprazole were the most potentially interactive drugs.
Conclusion
Drug-Food Interactions occur with commonly used drugs, for example omeprazole and acetylsalicylic acid. However, health teams do not know or identify a substantial part of interactions. This factor leads to an exposure to risks related to changes in drug response and patient safety.
References
Lopes EM, Oliveira EAR, Lima LHO, Formiga LMF, Freitas RM. Interações fármaco-alimento/nutriente potenciais em pacientes pediátricos hospitalizados. Rev Ciênc Farm Básica Apl. 2013 [citado 2016 set 28];34(1):131-5. Disponível em: http://repositorio.ufc.br/bitstream/riufc/7944/1/2013_art_lholima1.pdf
Lopes EM, Carvalho RBN, Freitas RM. Analysis of possible food/nutrient and drug interactions in hospitalized patients. Einstein. 2010;83(1):298-302. http://dx.doi.org/10.1590/s1679-45082010ao1672
Moura MRL, Reyes FG. Drug-nutrient interaction: A review. Rev Nutr. 2002;15(2):223-38. http://dx.doi.org/10.1590/S1415-52732002000200011
Wong CY, Chaudhry SI, Desai MM, Krumholz HM. Trends in comorbidity, disability, and polypharmacy in heart failure. Am J Med. 2011;124(2):136-43. http://dx.doi.org/10.1016/j.amjmed.2010.08.017
Passos MMB, Santos RC, Bergamini VG, Souza DC. Interações medicamentosas em pacientes internados na clínica médica de um hospital de ensino e fatores associados. Rev Bras Farm. 2012 [citado 2016 out 20]; 93(4):450-6. Disponível em: http://www.rbfarma.org.br/files/rbf-2012-93-4-9.pdf
Santos FC, Rosa PV, Rosa LHT, Pribbernow SCM. Avaliação do risco de internação hospitalar de idosos da comunidade no município de Porto Alegre. Estud Interdiscipl Envelhec. 2014 [citado 2016 nov 3];19(3):839-52. Disponível em: http://www.seer.ufrgs.br/index.php/RevEnvelhecer/ article/view/38139/33289
Burille A, Gerhardt TE. Chronic diseases, chronic problems: Agreements and disagreements with health services in therapeutic itineraries of rural men. Saúde Soc. 2014;23(2):664-76. http://dx.doi.org/10.1590/S0104-12902014000200025
Rufino GP, Gurgel MG, Pontes TC, Freire E. Evaluation of determining factors of the length of stay in medical clinic. Rev Bras Clin Med. 2012 [cited 2016 Nov 16];10(4):291-7. Available from: http://files.bvs.br/upload/S/1679-1010/2012/v10n4/a3043.pdf
Silveira EA, Dalastra L, Pagotto V. Polypharmacy, chronic diseases and nutritional markers in communitydwelling older. Rev Bras Epidemiol. 2014;17(4):818-29. http://dx.doi.org/10.1590/1809-4503201400040002
Bushra R, Aslam N, Khan AY. Food-drug interactions. Oman Med J. 2011 [cited 2016 Dec 4];26(2):77-83. Available from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3191675/11. Sandri M, Gewehr DM, Huth A, Moreira AC. Use of medicines and their potential interactions with foods in institutionalized elderly individuals. Sci Med. 2016 [cited 2016 Dec 15];26(4):ID23780. Available from: http://
revistaseletronicas.pucrs.br/fass/ojs/index.php/scientiamedica/article/view/23780/15055
Melo DAA, Nascimento ACS, Souza CAS, Silva WB, Faraoni AS. Identification of possible interactions of orally administered drug with food in hospitalized patients. Scientia Plena. 2014 [cited 2016 Jan 10];10(6):064061. Available from: https://www.scientiaplena.org.br/sp/article/view/1859/986
Peixoto JS, Salci MA, Radovanovic CAT, Salci TP, Torres MM, Carreira L. Riscos da interação droga-nutriente em idosos de instituição de longa permanência. Rev Gaúcha Enferm. 2012;33(3):156-64. http://dx.doi.org/10.1590/S1983-14472012000300021
Mengue SS, Bertoldi AD, Ramos LR, Farias MR, Oliveira MA, Tavares NUL, et al. Acesso e uso de medicamentos para hipertensão arterial no Brasil. Rev Saúde Pública. 2016;50 Supl2:1s-9. http://dx.doi.org/10.1590/s1518-8787.2016050006154
Lombardi NF, Mendes AEM, Luchetta RC, Reis WCT, Fávero MLD, Correr CJ. Análise das discrepâncias encontradas durante a conciliação medicamentosa na admissão de pacientes em unidades de cardiologia: um estudo descritivo. Rev Latino-Am Enferm. 2016;24:e2760. http://dx.doi.org/10.1590/1518-8345.0820.2760
Silva LD, Matos GC, Barreto BG, Albuquerque DC. Aprazamento de medicamentos por enfermeiros em prescrições de hospital sentinela. Texto Contexto Enferm. 2013;22(3):722-30. http://dx.doi.org/10.1590/S0104-07072013000300019
Lombardo M, Eserian JK. Fármacos e alimentos: interações e influências na terapêutica. Infarma. 2014 [citado 2017 dez 9]; 26(3):188-92. Disponível em: http://revistas.cff.org.br/?journal=infarma&page=article&op=view&path%5B%5D=632&path%5B%5D=pdf_15
Campos AFL, Torres SP, Lopes EM, Carvalho RBN, Freitas RM, Nunes LCC. Identification and analysis of antinutritional factors in possible interactions between medications and food/nutrients in hospitalized patients. Einstein. 2011;93(1):319-25. http://dx.doi.org/10.1590/s1679-45082011ao2026
Heldt T, Loss SH. Drug-nutrient interactions in the intensive care unit: Literature review and current recommendations. Rev Bras Ter Intens. 2013;25(2):162-7. http://dx.doi.org/10.5935/0103-507X.20130028
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Matheus Kirton dos ANJOS, Tainã Clarissa Santos da Silva de OLIVEIRA, Maiara Benevides MOREIRA, Samara Oliveira MOREIRA, Marluci Andrade Conceição STIPP, Graciele Oroski PAES
This work is licensed under a Creative Commons Attribution 4.0 International License.
