Cafeteria diet intake for fourteen weeks can cause obesity and insulin resistance in Wistar rats
Palabras clave:
Cafeteria diet, High-fat food, Insulin resistance, ObesityResumen
Objective
Obesity is a strong predictor of some kinds of diseases. High intake of high-fat foods contributes significantly to the growth of the obese population globally. The aim of this study was to verify if consumption of a cafeteria diet for fourteen weeks could increase white fat mass, body weight and skeletal muscle mass and promote insulin resistance in male Wistar rats.
Methods
Twenty animals were divided into two groups: control and obese. Both were fed standard chow and water ad libitum. Additionally, a cafeteria diet consisting of bacon, bologna sausage, sandwich cookies and soft drink was given to the obese group.
Results
The obese group was significantly heavier (p<0.0001) than controls from the second week until the end of the cafeteria-diet intervention. Absolute and relative fat mass, liver weight and Lee Index increased significantly (p<0.05) in the obese group. Furthermore, the obese group had lower (p<0.05) insulin sensitivity than the control group.
Conclusion
In conclusion, fourteen weeks of cafeteria diet promoted a progressive increase of fat mass and insulin resistance. Therefore, this is a great and inexpensive diet-induced insulin resistance model.
Citas
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Derechos de autor 2023 Danilo Antônio Corrêa PINTO JÚNIOR, Patricia Monteiro SERAPHIM
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
