Produto a base de yacon e modulação da microbiota, perfil de ácidos graxo e lipídico em ratas ovariectomizadas
Palavras-chave:
Dislipidemias, Ovariectomia, Prebióticos, YaconResumo
Objetivo
Este trabalho avaliou a modulação da microbiota gastrointestinal, do perfil de ácidos orgânicos e de lipídeos em ratas Wistar ovariectomizadas, sendo que algumas receberam dieta suplementada com 6% de fruto-oligossacarídeos e inulina, a partir do produto a base de yacon, e outras não.
Métodos
Analisou-se o peso do ceco, pH e ácidos orgânicos, microbiota do conteúdo cecal, colesterol total e frações.
Resultados
No grupo que recebeu a dieta suplementada durante todo o experimento ocorreu modulação benéfica da microbiota intestinal em função da fermentação dos fruto-oligossacarídeos/inulina, bem como aumento do perfil de lactato (p<0,05) e do nível de lipoproteina alta densidade (p<0,05).
Conclusão
Isso sugere que o hábito de consumo contínuo do yacon tem potencial para modular a microbiota intestinal, o perfil de ácidos orgânicos e para diminuir as dislipidemias.
Referências
World Health Organization. Diet, nutrition and the prevention of chronic diseases. Geneva: WHO; 2003.
Food and Agriculture Organization. Tecnical meeting on prebiotics: Food quality and standards service (AGNS). Rome: FAO; 2007.
Yildiz S. The Metabolism of fructooligosaccharides and fructooligosaccharide-related compounds in plants. Food Rev Int. 2011; 27(1):16-50.
Lobo AR, Colli C, Alvares EP, Filisetti TMCC. Effects of fructans-containing yacon (Smallanthus sonchifolius Poepp and Endl.) flour on caecum mucosal morphometry, calcium and magnesium balance, and bone calcium retention in growing rats. Br J Nutr. 2007; 97(4):776-85.
Roberfroid MB. Introducing inulin-type fructans. Br J Nutr. 2005; 93(Suppl. 1):525-56.
Geyer M, Manrique I, Degen L, Beglinger C. Effect of yacon (smallanthus sonchifolius) on colonic transit time in healthy volunteers. Digestion. 2008; 78(1):30-3.
Rodrigues FCR, Castro ASB, Rodrigues VC, Fernandes SA, Fontes EAF, Oliveira TT, et al. Yacon flour and bifidobacterium longum modulate bone health in rats. J Med Food. 2012; 15(7):664-70.
Valentova K, Stejskal D, Bartek J, Dvorackova S, Kren V, Ulrichova J, et al. Maca (Lepidium meyenii) and yacon (Smallanthus sonchifolius) in combination with silymarin as food supplements: In vivo safety assessment: Food Chem Toxicol. 2008; 46(3):1006-13.
Silva IMC, Sá EQC. Alimentos funcionais: um enfoque gerontológico. Rev Bras Clín Méd. 2012; 10(1):24-8.
Paula HAA. Efeito de um produto à base de yacon (Smallanthus sonchifolius) na modulação de indi cadores da saúde óssea em ratas wistar [douto rado]. Viçosa: Universidade de Federal de Viçosa; 2013.
Yun EY, Kim HS, Kim YE, Kang MK, Ma JE, Lee GD, et al. A case of anaphylaxis after the ingestion of yacon. Allergy Asthma Immunol Res. 2010; 2(2):149-52.
Reeves PC, Nielsen FH, Fahey GC. AIN-93 Purified diets for laboratory rodents: Final report of the American Institute of Nutrition Ad Hoc Writing Committee on the Reformulation of the AIN-76 A Rodent Diet. J Nutr. 1993; 123(11):1939-51.
Simões PA, Zamarioli A, Blóes P, Mazzocato FC, Pereira LHA, Volpon JB, et al. Effect of treadmill exercise on lumbar vertebrae in ovariectomized rats: Anthropometrical and mechanical analyses. Acta of Bioeng Biomech. 2008; 10(2):39-41.
Smiricky-Tjardes MR, Grieshop CM, Flickinger EA, Bauer LL, Fahey GC. Dietary galactooligosaccharides affect ileal and total-tract nutrient digestibility, ileal and fecal bacterial concentrations, and ileal fermentative characteristics of growing pigs. J Anim Sci. 2003; 81(10):2535-45.
American Public Health Association. Standard methods for the examination of dairy products. 17th ed. Washington (DC): APHA; 2004.
Weaver CM, Martin R, Story JA, Hutchinson I, Sanders L. Novel fibers increase bone calcium content and strength beyond efficiency of large intestine fermentation. J Agric Food Chem. 2010; 58(16):8952-7.
Genta S, Cabrera W, Habiba N, Ponsb J, Carilloc IM, Graud A, et al. Yacon syrup: Beneficial effects on obesity and insulin resistance in humans. Clin Nutr. 2009; 28(2):182-7.
Genta S, Cabrera WM, Grau A, Sánchez SS. Subchronic 4-month oral toxicity study of dried Smallanthus sonchifolius (yacon) roots as a diet supplement in rats. Food Chem Toxicol. 2005; 43(11):1657-65.
Sant’Anna MSL, Ferreira CLLF. Yacon (Smallanthus sonchifolius) no controle das doenças crônicas não transmissíveis. Nutr Br. 2013; 12(5):310-4.
Havenaar R. Intestinal health functions of colonic microbial metabolites: A review. Beneficial Microbes. 2011; 2(2):103-14.
Rodriguez-Cabezas ME, Camuesco D, Arribas B, Garrido-Mesa N, Comalada M, Bailón E, et al. The combination of fructooligosaccharides and resistantstarch shows prebiotic additive effects in rats. Clin Nutr. 2010; 29(6):832-9.
Gibson GR, Beatty ER, Wang X, Cummings JH. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterol. 1995; 108(4):975-82.
Paturi G, Butts CA, Stoklosinski H, Ansell J. Effects of early dietary intervention with a fermentable fibre on colonic microbiota activity and mucin gene expression in newly weaned rats. J Funct Foods. 2012; 4(2):520-30.
American Diabetes Association. Standars of medical care in diabetes. Diabetes Care. 2010; 33(Suppl. 1):S11-S61.
Charland SL, Cziraky MJ, Quimbo R. Achieving optimal lipid values in patients with dyslipidemia is associated with reduced risk of cardiovascular events. J Clin Lipidol. 2008; 2(5):343-53.
Castelli WP. Epidemiology of coronary heart disease: The Framingham study. Am J Med. 1984; 27(2A):4-12.
Passos LML, Park YK. Frutoligossacarídeos: impli cações na saúde humana e utilização em alimentos. Ciênc Rural. 2003; 33(2):385-90.
Fiodarliso M, Kok N, Desager JP, Goethal SF, Roberfroid M, Delzenne N. Dietary oligofructose lower triglycerides, phospholipids and cholesterol in serum and very low density lipoproteins of rats. Lipids. 1995; 30(2):163-7.
Yamomoto Y, Takahashi Y, Kawano M, Lizuka M, Matsumoto T, Shigeru S, et al. In vitro digestibilty and fermentability of levan and its hypocholesterolemic effects in rats. J Nutr Biochem. 1999; 10(1):13-8.
Kim M, Shin HS. The water-soluble extract of chicory influences serum and liver lipid concentrations, cecal short-chain fatty acid concentrations and fecal lipid excretion in rats. J Nutr. 1998; 128(10):1731-6.
Perucha VR. Propriedades funcionais da banana verde. Nutr Saúde e Perform. 2005 [acesso 2014 dez 8]; 26. Disponível em: http://www.brazilhost. com.br/bananaverde/propriedade.htm
Roberfroid MB. Prebiotics and probiotics: Are they functional foods? Am J Clin Nutr. 2000; 71(Suppl. 6):1682-7.
Aarsland A, Chinkes D, Wolfe RR. Contribuitions of de novo synthesis of fatty acids to total VLDL-trigliceride secretion during prolonged hyperglycemia/insulinemia in normal man. J Clin Invest. 1996; 98(9):2008-17.
Delzenne N, Kok N. Effects of fructans-type prebiotics on lipid metabolism. Am J Clin Nutr. 2001; 73(Suppl. 2):456-8.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2023 Joice de Fátima Laureano MARTINS, Viviane da Cruz RAFAEL, Edimar Aparecida FILOMENA, Fabiana Carvalho RODRIGUES, Sirlene Souza Rodrigues SARTORI, Célia Lúcia de Luces Fortes FERREIRA
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
