Polymorphism in the SIRT1 gene and parameters of metabolic syndrome in a sample of the adult Brazilian population
Keywords:
Body mass index, Metabolic syndrome, Obesity, Polymorphism, single nucleotide, Sirtuin 1Abstract
Objective
To evaluate whether the single nucleotide polymorphism rs7895833 (A/G) of the gene SIRT1 is associated with metabolic syndrome criteria in a sample of Brazilian adults.
Methods
Serum samples and oral mucosal cells were collected from 243 subjects aged 30 to 70 years. Biochemical, hormonal, and anthropometric data were obtained. The single nucleotide polymorphism rs7895833 (A/G) was analyzed by polymerase chain reaction using the amplification refractory mutation system.
Results
Among the 243 study subjects, 100 (41.15%) were classified as non-metabolic syndrome and 143 (58.85%), as metabolic syndrome. The frequency of the single nucleotide polymorphism rs7895833 (A/G) did not differ between the groups. However, 111 patients (45.67%) were overweight (body mass index: 25-29.9 kg/m2).Blood glucose, total cholesterol, triglycerides, very low density lipoprotein, low density lipoprotein, waist an hip circumferences, and blood pressure were higher in the metabolic syndrome group than in the non-metabolic syndrome group. Free thyroxine 4, grown hormone, and insulin levels were within the normal range. The
metabolic conditions of the patients with metabolic syndrome indicate biochemical, anthropometric, and hormonal changes characteristic of overweight and obesity.
Conclusion
The SIRT1 polymorphism rs7895833 (A/G) is not associated with the metabolic syndrome in the adult Brazilian population.
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Copyright (c) 2023 Marina Veloso de Oliveira MENEGUETTE, Camila Andréa de OLIVEIRA, Maria Helena de Melo LIMA, Kathleen Nicole PINA, Maria Esméria Corezola do AMARAL
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